Developing a goal-oriented SDI assessment approach using GIDEON - the Dutch SDI implementation strategy - as a case study

In 2008, the Dutch government approved the GIDEON document as a policy aiming at the implementation of the National Spatial Data Infrastructure (NSDI) in the Netherlands. The execution of GIDEON should take place by pursuing seven implementation strategies which lead to the achievement of the GIDEON goals. GIDEON also expresses the need to monitor the progress of implementing its strategies and realization of its goals. Currently, the work has been started on monitoring the GIDEON implementation strategies. However, there is still a lack of knowledge and methods to monitor GIDEON goals realization. The challenge is to come up with an approach to assess to what extent these goals are achieved. As a response to the challenge of assessing the GIDEON goals, this paper explores the possibility of using the Multi-view SDI assessment framework (Grus et al., 2007). This paper presents and discusses the method that applies the Multi-view SDI assessment framework, its indicators and measurement methods to create a GIDEON assessment approach. The method of creating a GIDEON assessment approach consists of several procedural steps: formulating specific GIDEON objectives, organizing a one-day workshop involving focus group of specific stakeholders responsible for creation and execution of NSDI, asking the workshop participants to select from a long list those indicators that best measure the achievement of each GIDEON goals. The key step of GIDEON approach is a one-day workshop. The workshop participants represented all organizations that cooperated and/or created GIDEON. The workshop consisted of two parts: first part explained the context of a challenge of assessing GIDEON, second part included participants activity to select and come to the consensus on the list of indicators that would best measure GIDEON goals realization. Additionally, the participants were asked to evaluate and express feedback on the usefulness of the method of creating GIDEON assessment approach. The results show that several indicators that relate to specific SDI goals could be selected by a significant number of workshop participants. The indicators that have been selected are not the final ones yet, but provide a guideline and form a base of what has to be measured when assessing GIDEON goals. Involving the representatives of all parties committed to GIDEON into the process of GIDEON assessment approach creation will strengthen its robustness and acceptance. The results of the feedback form filled by each participant show that the presented method is useful or very useful to create GIDEON assessment approach. Additionally, some of the participants provided already their own indicators which are very specific for Dutch SDI monitoring.The method presented in this research, assuming that SDI goals are defined and the organizations that participate in SDI creation are known, can be applied in any other country to develop country-specific and practical SDI assessment approach

Giving You Wings: Should the Food and Drug Administration Investigate the Safety of Red Bull and So-Called Energy Drinks?

Discussion of potential FDA regulation of energy drinks such as Red Bull

Applying Task Force Recommendations on Integrating Science and Practice in Health Service Psychology Education

The proper role of research skills and training to conduct research in professional psychology education has been controversial throughout the history of the field. An extensive effort was undertaken recently to address that issue and identify ways the field might move forward in a more unified manner. In 2015, the American Psychological Association (APA) Board of Educational Affairs convened a task force to address one of the recommendations made by the Health Service Psychology Education Collaborative in 2013. That recommendation stated that the education and training of health service psychologists (HSPs) include an integrative approach to science and practice that incorporates scientific-mindedness, training in research skills, and goes well beyond merely “consuming” research findings. The task force subsequently developed recommendations related to the centrality of science competencies for HSPs and how these competencies extend beyond training in evidence-based practice. This article discusses the findings of the task force and the implications of its recommendations for education and training in HSP. The challenges and opportunities associated with implementing these recommendations in HSP graduate programs are examined

Wat zijn de effecten van een open basisregistratie topografie na twee jaar?

Sinds 1 januari 2012 is basisregistratie topografie (BRT) vrij beschikbaar voor burgers. Wat het effect is op het gebruik is echter onbekend. Een monitor is ontwikkeld door Kadaster samen met Wageningen UR. Het bestand wordt meer gebruikt, bedrijven en ook burgers beginnen met het ontwikkelen van toegevoegde waarde producten en administratieve lasten voor overheidsorganisaties zijn afgenomen. Ook door het Kadaster wordt een open BRT als positief ervaren

De effecten van een open basisregistratie topografie (BRT)

Op 1 januari 2012 is basisregistratie topografie (BRT) als open data aan de maatschappij ter beschikking gesteld. Deze stap zal zeer waarschijnlijk aanzienlijke effecten hebben op het gebruik van deze gegevens. Wat deze effecten zijn is echter onbekend. Om meer inzicht in deze effecten te krijgen is door de Wageningen Universiteit en het Kadaster en monitor ontwikkeld. Deze monitor richt zich, via indicatoren, op het meten van de effecten op de maatschappij (externe effecten), de interactie tussen het Kadaster en de maatschappij (relatie effecten) en het Kadaster (interne effecten)

A large arteriovenous fistula steals a considerable part of systemic blood flow during veno-arterial extracorporeal circulation support in a porcine model

Background: Veno-arterial extracorporeal membrane oxygenation (V-A ECMO) is one of the most frequently used mechanical circulatory support devices. Distribution of extracorporeal membrane oxygenation flow depends (similarly as the cardiac output distribution) on regional vascular resistance. Arteriovenous fistulas (AVFs), used frequently as hemodialysis access, represent a low-resistant circuit which steals part of the systemic perfusion. We tested the hypothesis that the presence of a large Arteriovenous fistulas significantly changes organ perfusion during a partial and a full Veno-arterial extracorporeal membrane oxygenation support.Methods: The protocol was performed on domestic female pigs held under general anesthesia. Cannulas for Veno-arterial extracorporeal membrane oxygenation were inserted into femoral artery and vein. The Arteriovenous fistulas was created using another two high-diameter extracorporeal membrane oxygenation cannulas inserted in the contralateral femoral artery and vein. Catheters, flow probes, flow wires and other sensors were placed for continuous monitoring of haemodynamics and organ perfusion. A stepwise increase in extracorporeal membrane oxygenation flow was considered under beating heart and ventricular fibrillation (VF) with closed and opened Arteriovenous fistulas.Results: Opening of a large Arteriovenous fistulas (blood flow ranging from 1.1 to 2.2 L/min) resulted in decrease of effective systemic blood flow by 17%–30% (p < 0.01 for all steps). This led to a significant decrease of carotid artery flow (ranging from 13% to 25% after Arteriovenous fistulas opening) following VF and under partial extracorporeal membrane oxygenation support. Cerebral tissue oxygenation measured by near infrared spectroscopy also decreased significantly in all steps. These changes occurred even with maintained perfusion pressure. Changes in coronary artery flow were driven by changes in the native cardiac output.Conclusion: A large arteriovenous fistula can completely counteract Veno-arterial extracorporeal membrane oxygenation support unless maximal extracorporeal membrane oxygenation flow is applied. Cerebral blood flow and oxygenation are mainly compromised by the effect of the Arteriovenous fistulas. These effects could influence brain function in patients with Arteriovenous fistulas on Veno-arterial extracorporeal membrane oxygenation

Tear fluid biomarkers in ocular and systemic disease: potential use for predictive, preventive and personalised medicine

In the field of predictive, preventive and personalised medicine, researchers are keen to identify novel and reliable ways to predict and diagnose disease, as well as to monitor patient response to therapeutic agents. In the last decade alone, the sensitivity of profiling technologies has undergone huge improvements in detection sensitivity, thus allowing quantification of minute samples, for example body fluids that were previously difficult to assay. As a consequence, there has been a huge increase in tear fluid investigation, predominantly in the field of ocular surface disease. As tears are a more accessible and less complex body fluid (than serum or plasma) and sampling is much less invasive, research is starting to focus on how disease processes affect the proteomic, lipidomic and metabolomic composition of the tear film. By determining compositional changes to tear profiles, crucial pathways in disease progression may be identified, allowing for more predictive and personalised therapy of the individual. This article will provide an overview of the various putative tear fluid biomarkers that have been identified to date, ranging from ocular surface disease and retinopathies to cancer and multiple sclerosis. Putative tear fluid biomarkers of ocular disorders, as well as the more recent field of systemic disease biomarkers, will be shown

Pattern of the Divergence of Olfactory Receptor Genes during Tetrapod Evolution

The olfactory receptor (OR) multigene family is responsible for the sense of smell in vertebrate species. OR genes are scattered widely in our chromosomes and constitute one of the largest gene families in eutherian genomes. Some previous studies revealed that eutherian OR genes diverged mainly during early mammalian evolution. However, the exact period when, and the ecological reason why eutherian ORs strongly diverged has remained unclear. In this study, I performed a strict data mining effort for marsupial opossum OR sequences and bootstrap analyses to estimate the periods of chromosomal migrations and gene duplications of OR genes during tetrapod evolution. The results indicate that chromosomal migrations occurred mainly during early vertebrate evolution before the monotreme-placental split, and that gene duplications occurred mainly during early mammalian evolution between the bird-mammal split and marsupial-placental split, coinciding with the reduction of opsin genes in primitive mammals. It could be thought that the previous chromosomal dispersal allowed the OR genes to subsequently expand easily, and the nocturnal adaptation of early mammals might have triggered the OR gene expansion

Genomic Organization and Evolution of the Vomeronasal Type 2 Receptor-Like (OlfC) Gene Clusters in Atlantic Salmon, Salmo salar

There are three major multigene superfamilies of olfactory receptors (OR, V1R, and V2R) in mammals. The ORs are expressed in the main olfactory organ, whereas the V1Rs and V2Rs are located in the vomeronasal organ. Fish only possess one olfactory organ in each nasal cavity, the olfactory rosette; therefore, it has been proposed that their V2R-like genes be classified as olfactory C family G protein-coupled receptors (OlfC). There are large variations in the sizes of OR gene repertoires. Previous studies have shown that fish have between 12 and 46 functional V2R-like genes, whereas humans have lost all functional V2Rs, and frog sp. have more than 240. Pseudogenization of V2R genes is a prevalent event across species. In the mouse and frog genomes, there are approximately double the number of pseudogenes compared with functional genes. An oligonucleotide probe was designed from a conserved sequence from four Atlantic salmon OlfC genes and used to screen the Atlantic salmon bacterial artificial chromosome (BAC) library. Hybridization-positive BACs were matched to fingerprint contigs, and representative BACs were shotgun cloned and sequenced. We identified 55 OlfC genes. Twenty-nine of the OlfC genes are classified as putatively functional genes and 26 as pseudogenes. The OlfC genes are found in two genomic clusters on chromosomes 9 and 20. Phylogenetic analysis revealed that the OlfC genes could be divided into 10 subfamilies, with nine of these subfamilies corresponding to subfamilies found in other teleosts and one being salmon specific. There is also a large expansion in the number of OlfC genes in one subfamily in Atlantic salmon. Subfamily gene expansions have been identified in other teleosts, and these differences in gene number reflect species-specific evolutionary requirements for olfaction. Total RNA was isolated from the olfactory epithelium and other tissues from a presmolt to examine the expression of the odorant genes. Several of the putative OlfC genes that we identified are expressed only in the olfactory epithelium, consistent with these genes encoding odorant receptors